No or only mild liver fibrosis (LS kPa). Inside the group of patients with elevated ALT, had F or F liver fibrosis stage. Advanced liver fibrosis (LS kPa) was much more frequent in patients with elevated ALT in comparison to standard ALT group ( vs. Despite the fact that moderate or much more extreme liver fibrosis occured more often in sufferers with elevated ALT compared to regular ALT group ( vs,higher proprotion of sufferers with normal ALT had LS suggesting moderate (F) fibrosis stage. Within a fiveyear followup period the majority of the CHC patients with typical ALT had steady liver disease with no fibrosis progression. Conclusion: Our benefits prove that normal ALT in CHC will not normally mean “healthy liver” considering the fact that a great proportion of these individuals had minimal or moderate liver fibrosis and also the possibility of progression to additional FIIN-2 custom synthesis severe situation. We do recommend that individuals with typical ALT should really not be excluded a priori from antiviral treatment. Selection on antiviral therapy need to depend on various variables (e.g. histology,LS,symptoms,comorbidities) too as the motivation along with the age with the patient,in lieu of on ALT level alone. Disclosure of Interest: None declaredP IS OLDER AGE A Danger Aspect FOR HEPATOCELLULAR CARCINOMA Development IN Individuals WITH CHRONIC HEPATITIS C Even when SUSTAINED VIRUS ERADICATION IS REACHED G. Sirin,O. Senturk,A. Celebi,M. Sezikli,H. Yilmaz,S. Hulagu Gastroenterology,Derince Education and Analysis Hospital,Gastroenterology,Kocaeli University,Kocaeli,Turkey Speak to Email Address: gsirinlive Introduction: Hepatitis C virus (HCV) is one of the big leading causes of hepatocellular carcinoma (HCC) in Turkey. We aimed to clarify the clinical features of individuals with chronic hepatitis C who develop HCC right after gaining sustained viral response (SVR) to interferon (IFN)based remedy. Aims Methods: Clinical parameters of sufferers (imply age: years old,E K: ) who achieved a SVR from to in two reference center hospital had been evaluated. Final results: Eighteen patients developed HCC inside a median followup period of months (variety months). Cox regression analysis showed that the strongest predictive element of HCC occurrence was decrease platelet (x cellsmicroL) count (hazard ratio [HR] P.) followed by prolonged ( prothrombin time (HR P.) and larger AST ( IUL) level,(HR P.),just before IFN therapy. In the time of SVR,the predictive things of HCC occurrence had been larger AFP ( ngml) level (HR P.) and older ( years) age (HR P.). In multivariate analysis showed that larger AFP ( ngml) level and older ( years) age at SVR were independent variables with the development of HCC,as well.Disclosure of Interest: F. Berden: None declared,R. de Knegt Monetary help for study: BMS,Roche,Janssen,Lecture charge(s): AbbVie,BMS,Gilead,Roche,Norgine,Consultancy: AbbVie,BMS,Gilead,Norgine,J. den Hollander: None declared,M. van Vonderen: None declared,P. Friederich: None declared,B. vanUnited European Gastroenterology Journal (S) Conclusion: Individuals of older ( years old) age at SVR really should be viewed as incredibly meticulously to detect early HCC development soon after IFN therapy,specially that have larger AFP level,even when PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/19389808 SVR is reached. In patients with chronic HCV,viral eradication of HCV infection need to be accomplished at a young age as you possibly can to stop HCC development following IFN primarily based therapy. Disclosure of Interest: None declaredA if validated measurements had been obtained from every patient. Colombo Gastroenterology and Endoscopy Unit,Fondazione IRCCS Ospedale Maggiore Policlinico,Milan,Gastr.