Product Name :
5′-Fluoroindirubinoxime
Description:
5′-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM.
CAS:
861214-33-7
Molecular Weight:
295.27
Formula:
C16H10FN3O2
Chemical Name:
5′-fluoro-3-(hydroxyamino)-1H,2’H-[2,3′-biindol]-2′-one
Smiles :
ONC1=C(NC2=CC=CC=C12)C1C(=O)N=C2C=CC(F)=CC=12
InChiKey:
LBUXOYSDWHGJNP-UHFFFAOYSA-N
InChi :
InChI=1S/C16H10FN3O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,18,20,22H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
5′-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM.|Product information|CAS Number: 861214-33-7|Molecular Weight: 295.27|Formula: C16H10FN3O2|Chemical Name: 5′-fluoro-3-(hydroxyamino)-1H,2’H-[2,3′-biindol]-2′-one|Smiles: ONC1=C(NC2=CC=CC=C12)C1C(=O)N=C2C=CC(F)=CC=12|InChiKey: LBUXOYSDWHGJNP-UHFFFAOYSA-N|InChi: InChI=1S/C16H10FN3O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,18,20,22H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.GS-441524 Epigenetic Reader Domain 33 mg/mL (282.Omidenepag custom synthesis 22 mM; Need ultrasonic).PMID:32896226 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|5′-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively. 5′-Fluoroindirubinoxime (5’-FIO) exhibits IC50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5′-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.|In Vivo:|5′-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats.|Products are for research use only. Not for human use.|