treatmentFIGURE 1 Time/pressure curves of T-TAS assay utilizing AR-chips with healthy controls or RBDs individuals: (A) FVII deficiency, (B) FXI deficiency, (C) FX deficiency, or (D) FXIII deficiency, ahead of or after spiking with indicated treatment522 of|ABSTRACTPB0695|Outcomes of a Bleeding Problems Diagnostic Multidisciplinary Team Meeting for Diagnosing Unclassified Bleeding Disorder / Bleeding of Unknown CausePatient groupGender Male, n ( ) Female, n ( ) Total, n ( )Mean bleeding score (typical deviation) five.8 (3.four) Mean age, years (s t a n d a rd deviation) 37 (18)W. Thomas1; M. Ali1; A. Arora2; J. Prabhakaran2; K. Abu-Zeinah2; D. White1; S. MacDonald1; E. Symington1.Regsitered having a standard haemostatic disorder Registered as unclassified 1 (3) 34 (97) 35 (100) bleeding disorder 7 (19) 29 (81) 36 (100)Cambridge University Hospitals NHS Foundation Trust, Cambridge,United kingdom; University of Cambridge School of Clinical Medicine, Cambridge, United kingdom Background: Unclassified bleeding disorder (UBD) is ‘a clear bleeding tendency but typical haemostatic investigations’. There is certainly growing recognition of UBD; two.six of sufferers registered with the UK Haemophilia Center Doctors Organisation have UBD. We register such patients with our center so we can give haemostatic suggestions for menorrhagia, childbirth and invasive procedures. There are actually no diagnostic suggestions for UBD so in 2019 we setup a monthly multidisciplinary team (MDT) meeting, attended by doctors/nurses/clinical scientists, to standardise patient registration with UBD/bleeding disorders. Aims: Assessment of the bleeding disorders MDT outcomes at our center from Could 2019-November 2020. Strategies: A database was held of the patient particulars, condensed MCMDM-1 VWD bleeding score (BS) along with the outcome with the MDT discussion (e.g. register or discharge) and notes reviewed for further details. The project had approval as a service evaluation. Final results: 116 patients had been discussed; 35 registered as UBD, 36 with a traditional haemostatic disorder (mild coagulation factor deficiencies/VWD/platelet ROCK2 drug function problems) and 45 discharged with re-assurance that they did not have a significant bleeding tendency and outcomes are summarised in table 1. The BS from the individuals was considerably distinct across groups (P 0.01) and for person comparisons among groups the distinction was not significant in between individuals discharged with no a diagnosis of a bleeding disorder and these with a conventional haemostatic defect identified (imply bleeding score 4.3 v five.eight respectively), on the other hand in between those 2 groups and also the UBD group the BS was considerably different (P 0.001); the mean BS was 11.1 in UBD patients. TABLE 1 Traits of patients that have been discussed at the MDTGender Male, n ( ) Female, n ( ) Patient group Discharged with out a bleeding disorder and re-assurance 5 (11) 40 (89) 45 (100) Total, n ( ) Imply bleeding score (standard deviation) four.three (2.4) Imply age, years (s t a n d a rd deviation) 38 (18)11.1 (4.4)45 (13)Conclusions: UBD individuals have larger BS than individuals with standard haemostatic defects probably due to bias in registration patterns (i.e. the bar for registration is ‘higher’). A BS of four may well be considered considerable having said that this was the imply BS of patients discharged right after investigation with re-assurance highlighting the limitations diagnostically on the BS in UBD.PB0696|Implementation of a National Reference Service for Activity Testing, Typing, and Genoαvβ1 Purity & Documentation Typing of