Ersion in the manuscript. Funding: This study received no external funding.
Ersion with the manuscript. Funding: This study received no external funding. Institutional Critique Board Statement: This study was carried out in accordance with the recommendations with the Declaration of Helsinki and authorized by the Institutional Evaluation Board of San Raffaele Scientific Institute (MYOCAR, 24/01/2018). Informed Consent Statement: Informed consent was obtained from all subjects involved within the study. Information Availability Statement: Information is going to be made accessible, upon affordable request, by emailing the correspondent author. Conflicts of Interest: The authors declare no conflict of interest with -Irofulven Autophagy regards to the publication of this manuscript.AbbreviationsAAD AF AVB BA CAM antiarrhythmic drug atrial fibrillation atrioventricular block bradyarrhythmia continuous arrhythmia monitoringJ. Clin. Med. 2021, 10,12 ofCMR EMB FU ICD ILR LGE LVEF NSAT NSVT PVC PVS SVA VA VTcardiac magnetic resonance MNITMT Epigenetics endomyocardial biopsy stick to up implantable cardioverter defibrillator implantable loop recorder late gadolinium enhancement left ventricular ejection fraction nonsustained atrial tachyarrhythmia nonsustained ventricular tachycardia premature ventricular complexes programmed ventricular stimulation supraventricular arrhythmias ventricular arrhythmias ventricular tachycardia
Journal ofClinical MedicineArticleHumoral Response to Microbial Biomarkers in Rheumatoid Arthritis PatientsSeyedesomaye Jasemi 1 , Gian Luca Erre 2,three , Maria Luisa Cadoni 2,three , Marco Bo 1 and Leonardo A. Sechi 1,four, 3Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43b, 07100 Sassari, Italy; [email protected] (S.J.); [email protected] (M.B.) Division of Healthcare, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy; [email protected] (G.L.E.); [email protected] (M.L.C.) Dipartimento di SpecialitMediche, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy Struttura Complessa di Microbiologia e Virologia, Azienda Ospedaliera Universitaria di Sassari, 07100 Sassari, Italy Correspondence: [email protected]; Tel.: 39-Citation: Jasemi, S.; Erre, G.L.; Cadoni, M.L.; Bo, M.; Sechi, L.A. Humoral Response to Microbial Biomarkers in Rheumatoid Arthritis Individuals. J. Clin. Med. 2021, ten, 5153. https://doi.org/10.3390/jcm10215153 Academic Editors: Muh-Shi Lin and Andrew Chih Wei Huang Received: 30 September 2021 Accepted: 31 October 2021 Published: two NovemberAbstract: Background/Objective: Chronic humoral immune response against multiple microbial antigens may well play a important role in the etiopathogenesis of rheumatoid arthritis (RA). We aimed to assess the prevalence and magnitude of antibody response against numerous bacterial and viral immunogen peptides within the sera of RA individuals compared with the general population. Techniques: Polyclonal IgG antibodies (Abs) distinct for peptides derived from Porphyromonas gingivalis (RgpA, Kpg), Aggregatibacter actinomycetemcomitans (LtxA1, LtxA2), Mycobacterium avium subsp. paratuberculosis (MAP4027), Epstein arr virus (EBNA1, EBVBOLF), and human endogenous retrovirus (HERV-W env-su) were detected by ELISA in serum samples from 148 consecutive RA sufferers and 148 sex and age-matched healthy controls (HCs). Also, the presence of a connection in between the positivity as well as the titer of antibodies and RA descriptors was explored by bivariate correlation analysis. Benefits: RA sufferers exhibit a larger prevalence of humoral immune response against all tested peptides in comparison with HCs using a.