El Valle,H. Pitanga Lukashok Endoscopy,Instituto Ecuatoriano De Enfermedades Digestivas,University Hospital Omni,Espiritu Santo University,Guayaquil,Ecuador Speak to Email Address: carlosoakmyahoo.es Introduction: Atrophic gastritis (AG) is often a chronic disease,connected to gastric adenocarcinoma in addition if serious AG is present. Sydney program classifies AG as mild,moderate and severe,but with moderate interobserver agreement,as this method is according to a visual analogic scale (qualitative evaluation). Confocal endomicroscopy showed an accuracy of for diagnosis of gastric diseases,but when grading AG still remains a qualitative measure. Lately,new computer software referred to as “CellvizioViewer” (CV) permits to measure in micrometers (mm) the structures observed right after pCLE research. Aims Techniques: Based on the hypothesis that AG severity is correlated with crypts size diminution,the aim of this study will be to decide a quantitative strategy to classify the severity of AG measuring the crypt location and intercrypt spaces in individuals with AG. Soon after approval by the ethics committee consecutive sufferers that underwent to upper endoscopy (UE) Angiotensin II 5-valine evaluation have been integrated within this prospective study. Inclusion criteria: dyspepsia months,age !,no history of UE evaluation,AG at histopathology,acceptance to participate. Exclusion criteria: use of PPI ,antibiotics or NSAIDs,gastric cancer,gastric surgery,pregnancy,contraindication to fluorescein. During UE biopsy web-sites have been performed in accordance to Sydney system 1st using pCLE after which by biopsy forceps from the identical web page. At pCLE regular crypt was defined by utilizing the classification of Wang et al . Soon after histopathology confirm AG,crypts have been analyzed employing the CV application measuring the crypts diameters,to ascertain the location by elliptic location formula (A .d.d) and measuring intercrypt space. That space was defined because the mean of every measured distance amongst the studied crypt and its adjacent. The cutoff worth involving mild,moderate and severe AG,crypts region was classified across tertiles,expressing its distribution making use of a boxspot graphic. For relationship between crypt location (CA) and intercrypt space,quadratic polynomial regression was applied. Data was processed making use of IBMSPSSStatistics. Results: sufferers had been identified to possess AG,females ( having a imply age of . . and crypts had been analyzed. Histopathology showed AG: absent in (mild (moderate PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28550243 and serious of circumstances. At pCLE the mean CA was (and typical of imply intercrypt distance was . . Minimum standard CA was mm. Classifying AG crypts was established as stick to: mild atrophic CA (mm) variety: and ,moderate AG CA: and . Serious AG CA was . Quadratic polynomial regression established a statistically significant partnership between CA and intercrypt space Conclusion: Using pCLE criteria,severity of AG may be defined by means of crypt location and intercrypt space with values of mm and mm respectively. Disclosure of Interest: None declaredA Benefits: individuals have been included. have been male with imply age of years. N lesions had been of instances,positioned at: stomach ,esophagus ,bile duct and colon . The sensitivity was and specificity of ,(AUC.) with a PPV of and NPV . p value The observed concordance was . using a Kappa value of corresponding to a force of substantial agreement as outlined by Landis Koch criteria. Modifications in diagnostic and therapeutic strategy have been evident in . of circumstances ,directing the sampling in of circumstances and avoiding diagnostic or therapeutic approaches in all situations. Conclusion: pCLE is.